
Why is Alzheimer’s Disease So Difficult to Treat?
TED-Ed
5 mins 51 secs
Ages 11 - 17

This video explores the complexities of treating Alzheimer's Disease, focusing on the roles of beta-amyloid plaques and tau tangles in neuronal damage. It highlights ongoing research efforts to understand the disease's mechanisms and develop effective treatments, offering hope for future breakthroughs.
not everyone with plaques develops Alzheimer's. This suggests that other factors are also at play in the disease's progression. Another hallmark of Alzheimer's is the presence of neurofibrillary tangles inside neurons. These tangles are made of a protein called tau, which normally helps stabilize the internal structure of neurons. In Alzheimer's patients, tau proteins become abnormally modified and form tangles, disrupting the transport system within neurons and leading to cell death. The combination of beta-amyloid plaques and tau tangles is believed to contribute to the widespread neuronal damage and loss of brain tissue seen in Alzheimer's patients. However, the exact relationship between these two proteins and how they lead to the symptoms of Alzheimer's is still not fully understood. Research is ongoing to better understand the underlying mechanisms of Alzheimer's and to develop effective treatments. Scientists are exploring various approaches, including targeting beta-amyloid and tau proteins, as well as investigating the role of inflammation and other potential contributing factors. Despite the challenges, there is hope that continued research will lead to breakthroughs in the prevention and treatment of Alzheimer's Disease, ultimately improving the lives of millions of people affected by this devastating condition.